Marine-Lenhart syndrome with papillary thyroid carcinoma

Abstract

Graves′ disease with accompanying functioning nodules is known as Marine-Lenhart syndrome. Autonomously functioning thyroid nodules (AFTNs) also within Graves′ thyroid tissue are almost always bening in nature. A 45-year-old man developed hyperthyroidism due to the coexistence of Graves′ disease and AFTN. Total thyroidectomy was performed. The hyperfunctioning nodule with centrally hypoactive foci detected by technetium-99m thyroid scanning was histologically diagnosed as papillary thyroid carcinoma that was 2.5 cm in diameter. We report the presence of papillary thyroid carcinoma within AFTN in patients with Marine-Lenhart syndrome, which has not been reported so far.

Keywords

• Autonomously functioning thyroid nodule
• Graves′ disease
• hyperthyroidism
• Marine-Lenhart syndrome
• papillary microcarcinoma
• papillary thyroid carcinoma
• thyroid scintigraphy
• toxic nodular goitre