Nature Communications (Jul 2022)
Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology
Abstract
The Cryo-EM structures reported in this work reveal how heparin incorporates into α-syn fibril formation to determine fibril polymorphs. This highlights the role of biological polymers in the conformational selection and neuropathological regulation of amyloid fibrils.