Nature Communications (Mar 2022)
Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors
- Monika Graf,
- Marta Interlandi,
- Natalia Moreno,
- Dörthe Holdhof,
- Carolin Göbel,
- Viktoria Melcher,
- Julius Mertins,
- Thomas K. Albert,
- Dennis Kastrati,
- Amelie Alfert,
- Till Holsten,
- Flavia de Faria,
- Michael Meisterernst,
- Claudia Rossig,
- Monika Warmuth-Metz,
- Johannes Nowak,
- Gerd Meyer zu Hörste,
- Chloe Mayère,
- Serge Nef,
- Pascal Johann,
- Michael C. Frühwald,
- Martin Dugas,
- Ulrich Schüller,
- Kornelius Kerl
Affiliations
- Monika Graf
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- Marta Interlandi
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- Natalia Moreno
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- Dörthe Holdhof
- Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
- Carolin Göbel
- Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
- Viktoria Melcher
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- Julius Mertins
- Department of Neurology, Schlosspark-Klinik
- Thomas K. Albert
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- Dennis Kastrati
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- Amelie Alfert
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- Till Holsten
- Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
- Flavia de Faria
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- Michael Meisterernst
- Institute of Molecular Tumor Biology, University of Münster
- Claudia Rossig
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- Monika Warmuth-Metz
- Neuroradiological Reference Center, University Hospital Würzburg
- Johannes Nowak
- Neuroradiological Reference Center, University Hospital Würzburg
- Gerd Meyer zu Hörste
- Department of Neurology with Institute of Translational Neurology, University Hospital Münster
- Chloe Mayère
- Department of Genetic Medicine and Development, University of Geneva
- Serge Nef
- Department of Genetic Medicine and Development, University of Geneva
- Pascal Johann
- Swabian Children’s Cancer Center, Paediatric and Adolescent Medicine, University Medical Center Augsburg
- Michael C. Frühwald
- Swabian Children’s Cancer Center, Paediatric and Adolescent Medicine, University Medical Center Augsburg
- Martin Dugas
- Institute of Medical Informatics, University of Münster
- Ulrich Schüller
- Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
- Kornelius Kerl
- Department of Pediatric Hematology and Oncology, University Children’s Hospital Münster
- DOI
- https://doi.org/10.1038/s41467-022-29152-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Rhabdoid tumors (RT) are aggressive paediatric cancers with yet unknown cells of origin. Here, the authors establish genetically engineered mouse models of RT and, using single-cell RNA-seq and epigenomics, identify potential cells of origin for the SHH and MYC subtypes.
