Time-dependent assessment of stimulus-evoked regional dopamine release

Rachel N. Lippert; Anna Lena Cremer; Sharmili Edwin Thanarajah; Clio Korn; Thomas Jahans-Price; Lauren M. Burgeno; Marc Tittgemeyer; Jens C. Brüning; Mark E. Walton; Heiko Backes

doi:10.1038/s41467-018-08143-4

Nature Communications (Jan 2019)

Time-dependent assessment of stimulus-evoked regional dopamine release

Rachel N. Lippert,
Anna Lena Cremer,
Sharmili Edwin Thanarajah,
Clio Korn,
Thomas Jahans-Price,
Lauren M. Burgeno,
Marc Tittgemeyer,
Jens C. Brüning,
Mark E. Walton,
Heiko Backes

Affiliations

Rachel N. Lippert: Max Planck Institute for Metabolism Research
Anna Lena Cremer: Max Planck Institute for Metabolism Research
Sharmili Edwin Thanarajah: Max Planck Institute for Metabolism Research
Clio Korn: Department of Psychiatry, University of Oxford, Warneford Hospital
Thomas Jahans-Price: Department of Experimental Psychology, University of Oxford
Lauren M. Burgeno: Department of Experimental Psychology, University of Oxford
Marc Tittgemeyer: Max Planck Institute for Metabolism Research
Jens C. Brüning: Max Planck Institute for Metabolism Research
Mark E. Walton: Department of Experimental Psychology, University of Oxford
Heiko Backes: Max Planck Institute for Metabolism Research

DOI: https://doi.org/10.1038/s41467-018-08143-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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It has proven difficult to measure the release of neurotransmitters, such as dopamine, in the human brain. Here, the authors introduce and validate a new method that infers dopamine release based on minute-by-minute fluctuations of the positron emission tomography (PET) radioligand [11C]raclopride.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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