Stroke: Vascular and Interventional Neurology (Nov 2021)

Abstract 1122‐000026: Factors Associated with Gender Differences in Patients with Lewy Body Dementia

  • Chika P Onuoha,
  • Lidadi Agbomi,
  • Nneoma Madubuike,
  • Oreoluwa Coker,
  • Samuel I Nathaniel,
  • Nicolas Poupore,
  • Melissa Bailey,
  • Laurie Roley,
  • Richard Goodwin,
  • Rebecca Russ‐Sellers,
  • Thomas I Nathaniel

DOI
https://doi.org/10.1161/SVIN.01.suppl_1.000026
Journal volume & issue
Vol. 1, no. S1

Abstract

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Introduction: Several studies have investigated gender differences in patients with Lewy Body Dementia (LBD), however, whether the observed differences are associated with demographic and pharmacological factors is not fully understood. The current study tested the hypothesis that specific demographic or pharmacological factors may contribute to the observed gender difference. Methods: A 5‐year data collected from a regional registry from 608 LBD patients including 332 men and 276 women were analyzed. Factors associated with men and women patients with LBD were determined using the logistic regression model. Multicollinearity was evaluated using variance inflation factors (VIFs), with values greater than five suggestive of multicollinearity Results: The results indicate that Caucasian men (94.3% vs 83.3%) were more likely to present with LBD. In the adjusted analysis, increasing age (OR = 1.042, 95% CI, 1.025‐ 1.058, P ˂ 0.001) was more likely to be associated with women with LBD, while olanzapine (OR = 2.871, 95% CI, 1.902‐4.334, P˂ 0.001), buspirone (OR = 2.388, 95% CI, 1.527‐3.735, P˂ 0.001), escitalopram (OR = 1.444, 95% CI, 1.079‐1.932, P = 0.014) and tobacco use (OR = 1.424, 95% CI, 1.075‐1.887, P = 0.014) were associated with men with LBD Conclusions: More men presented with LBD compared to women. Our findings reveal specific demographic and pharmacological factors that contribute to gender differences among LBD patients.

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