Molecules (Oct 2024)

Alkaloids with Their Protective Effects Against A<i>β</i><sub>25-35</sub>-Induced PC-12 Cell Injury from the Tubers of <i>Pinellia pedatisecta</i> Schott

  • Xu Chen,
  • Yangang Cao,
  • Kaili Ye,
  • Yanling Liu,
  • Fangge Chi,
  • Ying Niu,
  • Di Lu,
  • Bingxian Zhao,
  • Lan Chen,
  • Xiaoke Zheng,
  • Weisheng Feng

DOI
https://doi.org/10.3390/molecules29215059
Journal volume & issue
Vol. 29, no. 21
p. 5059

Abstract

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Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] and one new natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circular dichroism (ECD). In addition, the results of the bioactivity evaluation showed that compounds (±)-3, 6, and 9 exhibited significantly protective effects against Aβ25-35-induced PC-12 cell injury and ameliorated cell viabilities by decreasing the levels of the reactive oxidative species (ROS) and mitochondrial membrane potential (MMP).

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