Nature Communications (Apr 2023)
Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening
- Mario Carucci,
- Julien Duez,
- Joel Tarning,
- Irene García-Barbazán,
- Aurélie Fricot-Monsinjon,
- Abdoulaye Sissoko,
- Lucie Dumas,
- Pablo Gamallo,
- Babette Beher,
- Pascal Amireault,
- Michael Dussiot,
- Ming Dao,
- Mitchell V. Hull,
- Case W. McNamara,
- Camille Roussel,
- Papa Alioune Ndour,
- Laura Maria Sanz,
- Francisco Javier Gamo,
- Pierre Buffet
Affiliations
- Mario Carucci
- Université Paris Cité, Inserm, UMR-1134, Biologie Intégré du Globule Rouge
- Julien Duez
- SYNSIGHT
- Joel Tarning
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Irene García-Barbazán
- Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III
- Aurélie Fricot-Monsinjon
- Université Paris Cité, Inserm, UMR-1134, Biologie Intégré du Globule Rouge
- Abdoulaye Sissoko
- Université Paris Cité, Inserm, UMR-1134, Biologie Intégré du Globule Rouge
- Lucie Dumas
- Université Paris Cité, Inserm, UMR-1134, Biologie Intégré du Globule Rouge
- Pablo Gamallo
- Global Health Medicines R&D, GlaxoSmith Kline (GSK)
- Babette Beher
- Université Paris Cité, Inserm, UMR-1134, Biologie Intégré du Globule Rouge
- Pascal Amireault
- Université Paris Cité, Inserm, UMR-1134, Biologie Intégré du Globule Rouge
- Michael Dussiot
- Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, INSERM
- Ming Dao
- Department of Materials Science and Engineering, Massachusetts Institute of Technology
- Mitchell V. Hull
- Calibr, a division of The Scripps Research Institute
- Case W. McNamara
- Calibr, a division of The Scripps Research Institute
- Camille Roussel
- Université Paris Cité, Inserm, UMR-1134, Biologie Intégré du Globule Rouge
- Papa Alioune Ndour
- Université Paris Cité, Inserm, UMR-1134, Biologie Intégré du Globule Rouge
- Laura Maria Sanz
- Global Health Medicines R&D, GlaxoSmith Kline (GSK)
- Francisco Javier Gamo
- Global Health Medicines R&D, GlaxoSmith Kline (GSK)
- Pierre Buffet
- Université Paris Cité, Inserm, UMR-1134, Biologie Intégré du Globule Rouge
- DOI
- https://doi.org/10.1038/s41467-023-37359-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Authors propose their splenic mimetic filtration method, microsphiltration, and utilise this approach in a drug-screen, to identify compounds that induce a stiffening effect on Plasmodium falciparum-infected erythrocytes. They proceed to assess safety and tolerability of one identified compound in a phase I clinical trial.
