Beilstein Journal of Organic Chemistry (Sep 2011)

Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles

  • Aurélie Dos Santos,
  • Laurent El Kaim,
  • Laurence Grimaud,
  • Caroline Ronsseray

DOI
https://doi.org/10.3762/bjoc.7.153
Journal volume & issue
Vol. 7, no. 1
pp. 1310 – 1314

Abstract

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Pyrazolidinones were prepared in a two-step sequence starting from α-hydrazonocarboxylic acids. After a four-component Ugi coupling, the resulting hydrazone was engaged in a copper triggered [3 + 2] cycloaddition/aerobic oxidation cascade.

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