Nature Communications (Aug 2018)

Crystal structure of human Mediator subunit MED23

  • Didier Monté,
  • Bernard Clantin,
  • Frédérique Dewitte,
  • Zoé Lens,
  • Prakash Rucktooa,
  • Els Pardon,
  • Jan Steyaert,
  • Alexis Verger,
  • Vincent Villeret

DOI
https://doi.org/10.1038/s41467-018-05967-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 7

Abstract

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Mediator is a large multi-subunits complex essential to the regulation of transcription by RNA pol II. Here the authors report the crystal structure of MED23—one of the largest subunits of the complex together with MED1 and MED14—revealing a complex architecture and filling an important gap in the structural characterization of Mediator.