Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314

Kimbria J. Blake; Pankaj Baral; Tiphaine Voisin; Ashira Lubkin; Felipe Almeida Pinho-Ribeiro; Kelsey L. Adams; David P. Roberson; Yuxin C. Ma; Michael Otto; Clifford J. Woolf; Victor J. Torres; Isaac M. Chiu

doi:10.1038/s41467-017-02448-6

Nature Communications (Jan 2018)

Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314

Kimbria J. Blake,
Pankaj Baral,
Tiphaine Voisin,
Ashira Lubkin,
Felipe Almeida Pinho-Ribeiro,
Kelsey L. Adams,
David P. Roberson,
Yuxin C. Ma,
Michael Otto,
Clifford J. Woolf,
Victor J. Torres,
Isaac M. Chiu

Affiliations

Kimbria J. Blake: Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School
Pankaj Baral: Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School
Tiphaine Voisin: Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School
Ashira Lubkin: Department of Microbiology, New York University School of Medicine
Felipe Almeida Pinho-Ribeiro: Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School
Kelsey L. Adams: Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School
David P. Roberson: Department of Neurobiology, Harvard Medical School
Yuxin C. Ma: Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School
Michael Otto: Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Disease, National Institutes of Health
Clifford J. Woolf: Department of Neurobiology, Harvard Medical School
Victor J. Torres: Department of Microbiology, New York University School of Medicine
Isaac M. Chiu: Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-017-02448-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Bacterial infection can cause pain but the underlying mechanism is unclear. This study shows pain induced in mice by methicillin-resistant Staphylococcus aureus infection is mediated by bacterial pore-forming toxins, and a sodium channel blocker QX-314 can alleviate infection-associated pain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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