Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior

Brian W. LeBlanc; Brent Cross; Kelsey A. Smith; Catherine Roach; Jimmy Xia; Yu-Chieh Chao; Joshua Levitt; Suguru Koyama; Christopher I. Moore; Carl Y. Saab

doi:10.1038/s41598-017-02753-6

Scientific Reports (May 2017)

Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior

Brian W. LeBlanc,
Brent Cross,
Kelsey A. Smith,
Catherine Roach,
Jimmy Xia,
Yu-Chieh Chao,
Joshua Levitt,
Suguru Koyama,
Christopher I. Moore,
Carl Y. Saab

Affiliations

Brian W. LeBlanc: Department of Neurosurgery, Rhode Island Hospital
Brent Cross: Department of Neurosurgery, Rhode Island Hospital
Kelsey A. Smith: Department of Neurosurgery, Rhode Island Hospital
Catherine Roach: Department of Neurosurgery, Rhode Island Hospital
Jimmy Xia: Department of Neurosurgery, Rhode Island Hospital
Yu-Chieh Chao: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University
Joshua Levitt: Center for Biomedical Engineering, Brown University
Suguru Koyama: Department of Neurosurgery, Rhode Island Hospital
Christopher I. Moore: Department of Neuroscience, Brown University
Carl Y. Saab: Department of Neurosurgery, Rhode Island Hospital

DOI: https://doi.org/10.1038/s41598-017-02753-6
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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Abstract We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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