Nature Communications (Aug 2020)
Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain
- Yiheng Tu,
- Zening Fu,
- Cuiping Mao,
- Maryam Falahpour,
- Randy L. Gollub,
- Joel Park,
- Georgia Wilson,
- Vitaly Napadow,
- Jessica Gerber,
- Suk-Tak Chan,
- Robert R. Edwards,
- Ted J. Kaptchuk,
- Thomas Liu,
- Vince Calhoun,
- Bruce Rosen,
- Jian Kong
Affiliations
- Yiheng Tu
- Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School
- Zening Fu
- Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University
- Cuiping Mao
- Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School
- Maryam Falahpour
- Center for Functional MRI, University of California San Diego
- Randy L. Gollub
- Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School
- Joel Park
- Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School
- Georgia Wilson
- Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School
- Vitaly Napadow
- Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School
- Jessica Gerber
- Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School
- Suk-Tak Chan
- Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School
- Robert R. Edwards
- Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Ted J. Kaptchuk
- Beth Israel Deaconess Medical Center, Harvard Medical School
- Thomas Liu
- Center for Functional MRI, University of California San Diego
- Vince Calhoun
- Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University
- Bruce Rosen
- Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School
- Jian Kong
- Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-17788-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Thalamocortical dysrhythmia is a key pathology of chronic pain. Here, the authors propose an analytical pipeline to study dynamic fMRI brain networks and demonstrate that chronic low back pain pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics.
