The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin

Julia Truch; Damien J. Downes; Caroline Scott; E. Ravza Gür; Jelena M. Telenius; Emmanouela Repapi; Ron Schwessinger; Matthew Gosden; Jill M. Brown; Stephen Taylor; Pak Leng Cheong; Jim R. Hughes; Douglas R. Higgs; Richard J. Gibbons

doi:10.1038/s41467-022-31194-7

Nature Communications (Jun 2022)

The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin

Julia Truch,
Damien J. Downes,
Caroline Scott,
E. Ravza Gür,
Jelena M. Telenius,
Emmanouela Repapi,
Ron Schwessinger,
Matthew Gosden,
Jill M. Brown,
Stephen Taylor,
Pak Leng Cheong,
Jim R. Hughes,
Douglas R. Higgs,
Richard J. Gibbons

Affiliations

Julia Truch: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Damien J. Downes: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Caroline Scott: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
E. Ravza Gür: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Jelena M. Telenius: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Emmanouela Repapi: MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Ron Schwessinger: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Matthew Gosden: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Jill M. Brown: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Stephen Taylor: MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Pak Leng Cheong: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Jim R. Hughes: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Douglas R. Higgs: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Richard J. Gibbons: MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford

DOI: https://doi.org/10.1038/s41467-022-31194-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The chromatin remodeling complex ATRX can promote gene expression, for example by binding G-quadruplexes (G4s) to prevent their negative effect on expression. Here the authors use a single-cell approach to show that only a subset of erythroid cells isolated from patients with ATRX mutations have reduced chromatin accessibility and alpha globin expression, suggesting a stochastic process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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