Research on the Centrifugal Driving of a Water-in-Oil Droplet in a Microfluidic Chip with Spiral Microchannel

Abstract

Combining the advantages of droplet-based microfluidics and centrifugal driving, a method for centrifugally driving W/O droplets with spiral microchannel is proposed in this paper. A physical model of droplet flow was established to study the flow characteristics of the W/O droplet in the spiral microchannel driven by centrifugal force, and kinematic analysis was performed based on the rigid body assumption. Then, the theoretical formula of droplet flow rate was obtained. The theoretical value was compared with the actual value measured in the experiments. The result shows that the trend of the theoretical value is consistent with the measured value, and the theoretical value is slightly larger than the experimentally measured value caused by deformation. Moreover, it is found that the mode of centrifugal driving with spiral microchannel has better flow stability than the traditional centrifugal driving structure. A larger regulation speed range can be achieved by adjusting the motor speed without using expensive equipment or precise instruments. This study can provide a basis and theoretical reference for the development of droplet-based centrifugal microfluidic chips.

Keywords

• droplet-based microfluidic
• spiral microchannel
• water-in-oil
• centrifugal microfluidic chip