Cognitive impairment in COVID-19: associations, pathogenesis and treatment questions

Abstract

Cognitive impairment (CI) can be neurological symptoms or complications of coronavirus disease 2019 (COVID-19). Among the pathogenetic mechanisms, the neurotropicity of the SARS- CoV-2 virus, endothelial dysfunction, coagulopathy, thrombus formation, systemic inflammatory reaction, the consequences of mechanical ventilation and drug sedation are considered. Treatment strategies for COVID-19 patients with CI have not yet been developed. The following tactics of patient management is advisable: prevention of re-infection, assessment and correction of the emotional state, treatment of cardiovascular diseases. The possibilities of vinpocetine in the treatment of CI after COVID-19 are discussed.

Keywords

• covid-19
• cognitive impairment
• treatment
• vinpocetine