MicroRNAs in the diagnosis, prognosis and treatment of cancer

Violaine Havelange; Catherine E.A. Heaphy; Ramiro Garzon

doi:10.4081/oncol.2008.203

Oncology Reviews (Dec 2011)

MicroRNAs in the diagnosis, prognosis and treatment of cancer

Violaine Havelange,
Catherine E.A. Heaphy,
Ramiro Garzon

Affiliations

Violaine Havelange: Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; Hematological section of the Human Genetic Center, Université Catholique de Louvain, Brussels
Catherine E.A. Heaphy: Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH
Ramiro Garzon: Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH

DOI: https://doi.org/10.4081/oncol.2008.203
Journal volume & issue: Vol. 2, no. 4

Abstract

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MicroRNAs (miRNAs) are small non-coding RNAs that regulate critical cell processes such as cell proliferation, apoptosis and differentiation by modulating gene expression. MiRNAs deregulation has been observed extensively in cancer. Elegant studies have demonstrated that miRNAs are involved in the initiation and progression of several malignancies. In this review we will address the role of miRNAs in the diagnosis and prognosis of cancer. The development of new drugs mimicking or blocking miRNAs will be discussed.

MicroRNAs - Cancer - MiRNAs profiling - Diagnosis - Prognosis - Treatment

Published in Oncology Reviews

ISSN: 1970-5565 (Print); 1970-5557 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Other systems of medicine; Medicine: Internal medicine
Website: https://www.frontierspartnerships.org/journals/oncology-reviews/

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