Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

Wenya Tian; Chenghai Sun; Mei Zheng; Jeffrey R. Harmer; Mingjia Yu; Yanan Zhang; Haidong Peng; Dongqing Zhu; Zixin Deng; Shi-Lu Chen; Mehdi Mobli; Xinying Jia; Xudong Qu

doi:10.1038/s41467-018-06528-z

Nature Communications (Oct 2018)

Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

Wenya Tian,
Chenghai Sun,
Mei Zheng,
Jeffrey R. Harmer,
Mingjia Yu,
Yanan Zhang,
Haidong Peng,
Dongqing Zhu,
Zixin Deng,
Shi-Lu Chen,
Mehdi Mobli,
Xinying Jia,
Xudong Qu

Affiliations

Wenya Tian: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Chenghai Sun: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Mei Zheng: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Jeffrey R. Harmer: Centre for Advanced Imaging, The University of Queensland
Mingjia Yu: School of Chemistry and Chemical Engineering, Beijing Institute of Technology
Yanan Zhang: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Haidong Peng: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Dongqing Zhu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Zixin Deng: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Shi-Lu Chen: School of Chemistry and Chemical Engineering, Beijing Institute of Technology
Mehdi Mobli: Centre for Advanced Imaging, The University of Queensland
Xinying Jia: Centre for Advanced Imaging, The University of Queensland
Xudong Qu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University

DOI: https://doi.org/10.1038/s41467-018-06528-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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The hexahydropyrrolo[2, 3-b]indole (HPI) framework is found in many natural products. Here, the authors discover a P450 enzyme and develop a whole-cell biocatalysis system that produces the HPI naseseazine C (NAS-C) and 30 NAS-C analogs, several of which show neuroprotective properties.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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