Nature Communications (May 2017)
TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension
- Rahul Kumar,
- Claudia Mickael,
- Biruk Kassa,
- Liya Gebreab,
- Jeffrey C. Robinson,
- Daniel E. Koyanagi,
- Linda Sanders,
- Lea Barthel,
- Christina Meadows,
- Daniel Fox,
- David Irwin,
- Min Li,
- B. Alexandre McKeon,
- Suzette Riddle,
- R. Dale Brown,
- Leslie E. Morgan,
- Christopher M. Evans,
- Daniel Hernandez-Saavedra,
- Angela Bandeira,
- James P. Maloney,
- Todd M. Bull,
- William J. Janssen,
- Kurt R. Stenmark,
- Rubin M. Tuder,
- Brian B. Graham
Affiliations
- Rahul Kumar
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- Claudia Mickael
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- Biruk Kassa
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- Liya Gebreab
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- Jeffrey C. Robinson
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- Daniel E. Koyanagi
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- Linda Sanders
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- Lea Barthel
- Department of Medicine, National Jewish Health
- Christina Meadows
- Department of Medicine, Anschutz Medical Campus
- Daniel Fox
- Department of Medicine, Anschutz Medical Campus
- David Irwin
- Department of Pediatrics and Medicine, Cardiovascular Pulmonary Research Laboratory, Anschutz Medical Campus
- Min Li
- Department of Pediatrics and Medicine, Cardiovascular Pulmonary Research Laboratory, Anschutz Medical Campus
- B. Alexandre McKeon
- Department of Pediatrics and Medicine, Cardiovascular Pulmonary Research Laboratory, Anschutz Medical Campus
- Suzette Riddle
- Department of Pediatrics and Medicine, Cardiovascular Pulmonary Research Laboratory, Anschutz Medical Campus
- R. Dale Brown
- Department of Pediatrics and Medicine, Cardiovascular Pulmonary Research Laboratory, Anschutz Medical Campus
- Leslie E. Morgan
- Department of Medicine, Anschutz Medical Campus
- Christopher M. Evans
- Department of Medicine, Anschutz Medical Campus
- Daniel Hernandez-Saavedra
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- Angela Bandeira
- Department of Medicine, Memorial S. Jose Hospital, Universidade de Pernambuco
- James P. Maloney
- Department of Medicine, Anschutz Medical Campus
- Todd M. Bull
- Department of Medicine, Anschutz Medical Campus
- William J. Janssen
- Department of Medicine, National Jewish Health
- Kurt R. Stenmark
- Department of Pediatrics and Medicine, Cardiovascular Pulmonary Research Laboratory, Anschutz Medical Campus
- Rubin M. Tuder
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- Brian B. Graham
- Department of Medicine, Program in Translational Lung Research, Anschutz Medical Campus
- DOI
- https://doi.org/10.1038/ncomms15494
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that interference with the activation process prevents disease development.
