Nature Communications (Oct 2018)
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism
- Giuseppina Arbore,
- Erin E. West,
- Jubayer Rahman,
- Gaelle Le Friec,
- Nathalie Niyonzima,
- Mehdi Pirooznia,
- Ilker Tunc,
- Polychronis Pavlidis,
- Nicholas Powell,
- Yuesheng Li,
- Poching Liu,
- Aude Servais,
- Lionel Couzi,
- Veronique Fremeaux-Bacchi,
- Leo Placais,
- Alastair Ferraro,
- Patrick R. Walsh,
- David Kavanagh,
- Behdad Afzali,
- Paul Lavender,
- Helen J. Lachmann,
- Claudia Kemper
Affiliations
- Giuseppina Arbore
- Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute
- Erin E. West
- Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Jubayer Rahman
- Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Gaelle Le Friec
- School of Immunology and Microbial Sciences, King’s College London
- Nathalie Niyonzima
- Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Mehdi Pirooznia
- Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Ilker Tunc
- Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Polychronis Pavlidis
- School of Immunology and Microbial Sciences, King’s College London
- Nicholas Powell
- School of Immunology and Microbial Sciences, King’s College London
- Yuesheng Li
- Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Poching Liu
- Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Aude Servais
- Service de Néphrologie adulte, Hôpital Necker
- Lionel Couzi
- Nephrologie,Transplantation, Dialyse, CHU Bordeaux, and CNRS-UMR 5164 Immuno ConcEpT, Université de Bordeaux
- Veronique Fremeaux-Bacchi
- Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, and INSERM UMR S1138, Centre de Recherche des Cordeliers
- Leo Placais
- Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Alastair Ferraro
- Department of Renal Medicine, Nottingham University Hospitals, NHS Trust
- Patrick R. Walsh
- National Renal Complement Therapeutics Centre, Institute of Cellular Medicine, Newcastle University
- David Kavanagh
- National Renal Complement Therapeutics Centre, Institute of Cellular Medicine, Newcastle University
- Behdad Afzali
- Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
- Paul Lavender
- School of Immunology and Microbial Sciences, King’s College London
- Helen J. Lachmann
- UK National Amyloidosis Centre, Division of Medicine, University College London, Royal Free Campus
- Claudia Kemper
- School of Immunology and Microbial Sciences, King’s College London
- DOI
- https://doi.org/10.1038/s41467-018-06706-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential for inducing optimal activation and effector functions of human CD8 T cells.
