Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages

Tadashi Maemura; Makoto Kuroda; Tammy Armbrust; Seiya Yamayoshi; Peter J. Halfmann; Yoshihiro Kawaoka

doi:10.1128/mBio.01987-21

mBio (Oct 2021)

Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages

Tadashi Maemura,
Makoto Kuroda,
Tammy Armbrust,
Seiya Yamayoshi,
Peter J. Halfmann,
Yoshihiro Kawaoka

Affiliations

Tadashi Maemura: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Makoto Kuroda: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Tammy Armbrust: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Seiya Yamayoshi: ORCiD; Division of Virology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Peter J. Halfmann: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Yoshihiro Kawaoka: ORCiD; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA

DOI: https://doi.org/10.1128/mBio.01987-21
Journal volume & issue: Vol. 12, no. 5

Abstract

Read online

Viruses infect cells mainly via specific receptors at the cell surface. Antibody-dependent enhancement (ADE) of infection is an alternative mechanism of infection for viruses to infect immune cells that is mediated by antibodies and IgG receptors (FcγRs).

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal