Association of novel obesity and lipid indices with chronic kidney disease risk in South Indians

Abstract

Obesity has emerged as a risk factor for the Chronic kidney disease (CKD). Recent research propose novel obesity indices like Lipid accumulation product (LAP), Visceral adiposity index (VAI), Cardiometabolic index (CMI) to be associated with CKD risk. We aimed to evaluate the association between novel obesity indices and CKD risk indicators such as estimated glomerular filtration rate (eGFR), urine albumin excretion. Anthropometry measures, plasma lipids, eGFR estimation from serum creatinine and urine albumin creatinine ratio (urine ACR) were performed in 60 apparently healthy adults visiting the health checkup clinic. The subjects were divided based on Body mass index (BMI) as non-obese (n=22) and obese (n=38) groups. Their eGFR and urine ACR were compared using independent t-test or Mann-Whitney test. Spearman correlation test determined the association of obesity and lipid indices with eGFR, urine ACR. Anthropometric measures - BMI, WC (waist circumference), lipid indices - TC/HDLc, LDLc/HDLc ratios, and obesity indices - LAP, CMI were significantly higher in the obese group (p [J Med Allied Sci. 2022; 12(2):58-64]

Keywords

• cardiometabolic index
• chronic kidney disease
• lipid accumulation product
• obesity
• visceral adiposity index