Nature Communications (Nov 2020)
Common diseases alter the physiological age-related blood microRNA profile
- Tobias Fehlmann,
- Benoit Lehallier,
- Nicholas Schaum,
- Oliver Hahn,
- Mustafa Kahraman,
- Yongping Li,
- Nadja Grammes,
- Lars Geffers,
- Christina Backes,
- Rudi Balling,
- Fabian Kern,
- Rejko Krüger,
- Frank Lammert,
- Nicole Ludwig,
- Benjamin Meder,
- Bastian Fromm,
- Walter Maetzler,
- Daniela Berg,
- Kathrin Brockmann,
- Christian Deuschle,
- Anna-Katharina von Thaler,
- Gerhard W. Eschweiler,
- Sofiya Milman,
- Nir Barziliai,
- Matthias Reichert,
- Tony Wyss-Coray,
- Eckart Meese,
- Andreas Keller
Affiliations
- Tobias Fehlmann
- Chair for Clinical Bioinformatics, Saarland University
- Benoit Lehallier
- Department of Neurology and Neurological Sciences, Stanford University
- Nicholas Schaum
- Department of Neurology and Neurological Sciences, Stanford University
- Oliver Hahn
- Department of Neurology and Neurological Sciences, Stanford University
- Mustafa Kahraman
- Chair for Clinical Bioinformatics, Saarland University
- Yongping Li
- Chair for Clinical Bioinformatics, Saarland University
- Nadja Grammes
- Chair for Clinical Bioinformatics, Saarland University
- Lars Geffers
- Luxembourg Center for Systems Biomedicine
- Christina Backes
- Chair for Clinical Bioinformatics, Saarland University
- Rudi Balling
- Luxembourg Center for Systems Biomedicine
- Fabian Kern
- Chair for Clinical Bioinformatics, Saarland University
- Rejko Krüger
- Luxembourg Center for Systems Biomedicine
- Frank Lammert
- Internal Medicine, Saarland University
- Nicole Ludwig
- Human Genetics, Saarland University
- Benjamin Meder
- Internal Medicine, University Hospital Heidelberg
- Bastian Fromm
- Department of Molecular Biosciences, Stockholm University
- Walter Maetzler
- Department of Neurology, Christian-Albrechts-Universität zu Kiel
- Daniela Berg
- Department of Neurology, Christian-Albrechts-Universität zu Kiel
- Kathrin Brockmann
- TREND study center Tübingen
- Christian Deuschle
- TREND study center Tübingen
- Anna-Katharina von Thaler
- TREND study center Tübingen
- Gerhard W. Eschweiler
- Geriatric Center and the Department of Psychiatry and Psychotherapy, University Hospital Tübingen
- Sofiya Milman
- The Institute for Aging Research, Albert Einstein College of Medicine
- Nir Barziliai
- The Institute for Aging Research, Albert Einstein College of Medicine
- Matthias Reichert
- Internal Medicine, Saarland University
- Tony Wyss-Coray
- Department of Neurology and Neurological Sciences, Stanford University
- Eckart Meese
- Human Genetics, Saarland University
- Andreas Keller
- Chair for Clinical Bioinformatics, Saarland University
- DOI
- https://doi.org/10.1038/s41467-020-19665-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Aging is a key risk factor for chronic diseases of the elderly. Here the authors perform large-scale miRNA profiling of blood from individuals of a range of ages and show that common diseases alter the physiological age-related blood microRNA profile.
