Nature Communications (Apr 2018)
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
- David Z. Pan,
- Kristina M. Garske,
- Marcus Alvarez,
- Yash V. Bhagat,
- James Boocock,
- Elina Nikkola,
- Zong Miao,
- Chelsea K. Raulerson,
- Rita M. Cantor,
- Mete Civelek,
- Craig A. Glastonbury,
- Kerrin S. Small,
- Michael Boehnke,
- Aldons J. Lusis,
- Janet S. Sinsheimer,
- Karen L. Mohlke,
- Markku Laakso,
- Päivi Pajukanta,
- Arthur Ko
Affiliations
- David Z. Pan
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Kristina M. Garske
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Marcus Alvarez
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Yash V. Bhagat
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- James Boocock
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Elina Nikkola
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Zong Miao
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Chelsea K. Raulerson
- Department of Genetics, University of North Carolina
- Rita M. Cantor
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Mete Civelek
- Department of Biomedical Engineering, University of Virginia
- Craig A. Glastonbury
- Big Data Institute, University of Oxford
- Kerrin S. Small
- Department of Twin Research and Genetic Epidemiology, King’s College
- Michael Boehnke
- Department of Biostatistics, University of Michigan
- Aldons J. Lusis
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Janet S. Sinsheimer
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Karen L. Mohlke
- Department of Genetics, University of North Carolina
- Markku Laakso
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital
- Päivi Pajukanta
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- Arthur Ko
- Department of Human Genetics, David Geffen School of Medicine at UCLA
- DOI
- https://doi.org/10.1038/s41467-018-03554-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
GWAS have identified numerous genetic loci for BMI and related traits. Here, Pan et al. generate Promoter Capture Hi-C data for human white adipocytes and integrate these with data of transcription factor motifs, RNA-seq and GWAS to identify eQTL-eGene relationships mediated by chromosomal interactions.
