Nature Communications (Nov 2017)
RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
- Oz Solomon,
- Ayelet Di Segni,
- Karen Cesarkas,
- Hagit T. Porath,
- Victoria Marcu-Malina,
- Orel Mizrahi,
- Noam Stern-Ginossar,
- Nitzan Kol,
- Sarit Farage-Barhom,
- Efrat Glick-Saar,
- Yaniv Lerenthal,
- Erez Y. Levanon,
- Ninette Amariglio,
- Ron Unger,
- Itamar Goldstein,
- Eran Eyal,
- Gidi Rechavi
Affiliations
- Oz Solomon
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Ayelet Di Segni
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Karen Cesarkas
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Hagit T. Porath
- The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- Victoria Marcu-Malina
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Orel Mizrahi
- Department of Molecular Genetics, Weizmann Institute of Science
- Noam Stern-Ginossar
- Department of Molecular Genetics, Weizmann Institute of Science
- Nitzan Kol
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Sarit Farage-Barhom
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Efrat Glick-Saar
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Yaniv Lerenthal
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Erez Y. Levanon
- The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- Ninette Amariglio
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Ron Unger
- The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University
- Itamar Goldstein
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Eran Eyal
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- Gidi Rechavi
- Cancer Research Center, Sheba Medical Center, Tel Hashomer
- DOI
- https://doi.org/10.1038/s41467-017-01458-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Adenosine deaminase acting on RNA 1 (ADAR1) edits adenosine to inosine. Here the authors, using parallel analysis of RNA secondary structure sequencing, provide evidence that ADAR1 induces sequence-context-dependent RNA secondary structures changes, often leading to stabilization of the RNA duplex.
