Nature Communications (Nov 2020)
Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis
- Qian Liu,
- Lisa C. Zaba,
- Ansuman T. Satpathy,
- Michelle Longmire,
- Wen Zhang,
- Kun Li,
- Jeffrey Granja,
- Chuang Guo,
- Jun Lin,
- Rui Li,
- Karen Tolentino,
- Gabriela Kania,
- Oliver Distler,
- David Fiorentino,
- Lorinda Chung,
- Kun Qu,
- Howard Y. Chang
Affiliations
- Qian Liu
- Department of Oncology, The First Affiliated Hospital of USTC, Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China
- Lisa C. Zaba
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine
- Ansuman T. Satpathy
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine
- Michelle Longmire
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine
- Wen Zhang
- Department of Oncology, The First Affiliated Hospital of USTC, Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China
- Kun Li
- Department of Oncology, The First Affiliated Hospital of USTC, Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China
- Jeffrey Granja
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine
- Chuang Guo
- Department of Oncology, The First Affiliated Hospital of USTC, Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China
- Jun Lin
- Department of Oncology, The First Affiliated Hospital of USTC, Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China
- Rui Li
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine
- Karen Tolentino
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine
- Gabriela Kania
- Department of Rheumatology, University Hospital Zurich
- Oliver Distler
- Department of Rheumatology, University Hospital Zurich
- David Fiorentino
- Department of Dermatology, Stanford University School of Medicine
- Lorinda Chung
- Department of Dermatology, Stanford University School of Medicine
- Kun Qu
- Department of Oncology, The First Affiliated Hospital of USTC, Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China
- Howard Y. Chang
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19702-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Systemic sclerosis (SSc) is a disease with manifestation in the skin and immune etiology, but the pathogenic immune cell types remain unidentified. Here the authors use ATAC-seq to profile chromatin landscapes of skin samples from patients with SSc to implicate skin dendritic cells for having the strongest disease-associated epigenetic changes.
