Analysis of Cross-species Anatomical Connection Differences Between Human and Macaque Broca Region

Abstract

On the basis of the idea of comparative neuroscience, the brain atlas registration method was used to extract Broca target brain regions and 10 regions of interest from each subject brain of humans and macaques, and a connectivity fingerprint was constructed from the Broca area of the subject's brain to 10 target brain areas. From the perspective of brain connection structure, cross-species connection difference of Broca regions in human brain and macaque brain was analyzed. Aiming at the problem of uneven distribution of sample characteristics, the independent sample t test method was used to analyze the connection difference between the Broca brain area and a certain target brain area from the perspective of the overall mean value of the species. Aiming at the problem of small sample size and insufficient ability to describe the results, the statistical analysis method of permutation test was used, and the reliability of the experimental results was analyzed through a large number of calculations. In addition, the homologous fiber bundles in the brains of human and rhesus monkeys were used to reconstruct the connectivity fingerprints of the Broca area, and the generated fingerprints were compared and analyzed with the above results. The final results shows that the overall mean difference between the Broca brain regions of human and macaque brains and most brain regions of interest is small, and the change trend of the connectivity fingerprints of the two species has a high degree of fit, which indicates that anatomically homologous Broca region also has high cross-species consistency in connection structure.

Keywords

• broca area
• comparative neuroscience
• connectivity fingerprints
• probabilistic tractography
• nmr