Prinzmetal angina: new approaches to pathogenesis and treatment

Abstract

The article contains modern data on vasospastic angina ethiology and pathogenesis, discussing possible genetic and neuro-humoral factors. Rho-kinase role in coronary spasm mechanisms is emphasized. New pharmaceutical approaches to Prinzmetal angina treatment, as well as perspectives of its surgery correction, are reviewed.

Keywords

• prinzmetal angina
• coronary spasm pathogenesis
• rho-kinase
• fasudil
• coronary angioplasty