ANTI-INFLAMMATORY ACTIVITY OF STEM BARK DICHLOROMETHANE FRACTION Syzygium samarangense EXTRACT AS COX-2 INHIBITOR: A BIOINFORMATICS APPROACH

Abstract

Syzygium samarangense is a plant that is rich in flavonoid compounds. Previous research revealed that the dichloromethane fraction from the stem bark extract contained four bioactive compounds, namely, pinocembrin, uvangoletin, stercurensin, and aurentiacin, which had good antioxidant activity. However, research on the potential of these four compounds as an anti-inflammatory has not been revealed. This study aims to continue previous research in revealing the potential of compounds in the dichloromethane fraction of S. samarangense extract as an anti-inflammatory agent in silico COX-2 inhibitors. This study uses in silico biocomputation, including drug-likeness analysis and molecular docking analysis using COX-2 protein and the control drug rofecoxib. The results showed that there are compounds that have the potential as anti-inflammatory compounds, namely pinocembrin. However, further studies, such as in vitro and in vivo, are still needed to reveal its potential as an anti-inflammatory agent

Keywords

• anti-inflammatory
• cox-2
• syzygium samarangense
• in silico