INTRA-ERYTHROCYTE INVASION OF ESCHERICHIA COLI STRAINS WITH VARIOUS LEVELS OF ANTIHEMOGLOBIN ACTIVITY IN EXPERIMENT

Abstract

Aim. Study of intra-erythrocyte invasion of Escherichia coli strains with various levels of antihemoglobin activity on a model of generalized infection. Materials and methods. Experiments were carried out on 72 male mice. Generalized infection was induced by intravenous administration of E.coli strain day culture suspension with various values of hemolytic and antihemoglobin activity. The levels of hemoglobin in animal blood was determined by hemoglobin-cyanide method. Intra-erythrocyte invasion of E.coli was studied by using laser scanning confocal microscopy (LSCM). Results. The largest decline (p

Keywords

• escherichia coli
• erythrocytes
• intra-cellular invasion
• hemolytic activity
• antihemoglobin activity