NiH-catalyzed anti-Markovnikov hydroamidation of unactivated alkenes with 1,4,2-dioxazol-5-ones for the direct synthesis of N-alkyl amides

Abstract

Hydroamidation of unactivated alkenes is an efficient way to introduce nitrogen-based functional groups to alkenes, however the regioselectivity requires directing groups. Here, the authors report the ligand-controlled NiH-catalyzed anti-Markovnikov intermolecular hydroamidation of unactivated alkenes with dioxazolones for the direct synthesis of N-alkyl amides.