Differential S-phase progression after irradiation of p53 functional versus non-functional tumour cells

Abstract

Background. Many pathways seem to be involved in the regulation of the intra-S-phase checkpoint after exposure to ionizing radiation, but the role of p53 has proven to be rather elusive. Here we have a closer look at the progression of irradiated cells through S-phase in dependence of their p53 status.

Keywords

• x-rays
• intra-s-phase checkpoint
• flow cytometry
• relative movement