Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics

Abstract

About one fourth of Lewy body disease (LBD) patients show cortical β-amyloid load, basically a hallmark of Alzheimer disease (AD). Using [11C]PIB-PET, we tested whether LBD patients with β-amyloid burden differ from those without with respect to demographic, clinical, biochemical and genetic parameters.Thirty-five LBD subjects (9 patients with Lewy body dementia, DLB; 12 demented Parkinson patients, PDD; 14 non-demented PD, PDND) underwent [11C]PIB-PET, and were classified as either PIB(+) or PIB(−) according to cortical PIB uptake. PIB(+) and PIB(−) patients were then compared according to demographic, clinical, biochemical and genetic parameters.None of the PDND, but four PDD and four DLB subjects were PIB(+). In PIB(+) subjects, ApoE4 prevalence was higher, CSF Abeta42 levels were lower and, among demented patients, PIB-binding was associated with a lower MMSE score. Motor symptoms were not associated with PIB binding. Thus, LBD patients with cortical β-amyloid show characteristics usually observed in AD.

Keywords

• Aged
• Amyloid metabolism
• Cerebrospinal fluid
• Diagnostic imaging
• Lewy body disease variant