Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation

Franck Martin; Jean-François Ménétret; Angelita Simonetti; Alexander G. Myasnikov; Quentin Vicens; Lydia Prongidi-Fix; S. Kundhavai Natchiar; Bruno P. Klaholz; Gilbert Eriani

doi:10.1038/ncomms12622

Nature Communications (Aug 2016)

Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation

Franck Martin,
Jean-François Ménétret,
Angelita Simonetti,
Alexander G. Myasnikov,
Quentin Vicens,
Lydia Prongidi-Fix,
S. Kundhavai Natchiar,
Bruno P. Klaholz,
Gilbert Eriani

Affiliations

Franck Martin: Architecture et Réactivité de l’ARN, Centre National de la Recherche Scientifique (CNRS) UPR9002, Institute of Molecular and Cellular Biology (IBMC), Université de Strasbourg
Jean-François Ménétret: Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC (Institute of Genetics and of Molecular and Cellular Biology)
Angelita Simonetti: Architecture et Réactivité de l’ARN, Centre National de la Recherche Scientifique (CNRS) UPR9002, Institute of Molecular and Cellular Biology (IBMC), Université de Strasbourg
Alexander G. Myasnikov: Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC (Institute of Genetics and of Molecular and Cellular Biology)
Quentin Vicens: Architecture et Réactivité de l’ARN, Centre National de la Recherche Scientifique (CNRS) UPR9002, Institute of Molecular and Cellular Biology (IBMC), Université de Strasbourg
Lydia Prongidi-Fix: Architecture et Réactivité de l’ARN, Centre National de la Recherche Scientifique (CNRS) UPR9002, Institute of Molecular and Cellular Biology (IBMC), Université de Strasbourg
S. Kundhavai Natchiar: Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC (Institute of Genetics and of Molecular and Cellular Biology)
Bruno P. Klaholz: Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC (Institute of Genetics and of Molecular and Cellular Biology)
Gilbert Eriani: Architecture et Réactivité de l’ARN, Centre National de la Recherche Scientifique (CNRS) UPR9002, Institute of Molecular and Cellular Biology (IBMC), Université de Strasbourg

DOI: https://doi.org/10.1038/ncomms12622
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 7

Abstract

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Prokaryotic translation initiation involves mRNA-ribosomal RNA base pairing interactions. Here, the authors provide evidence for a similar base pairing interactions occurring between the human h4 mRNA and helix 16 of the small subunit rRNA to position the correct AUG codon in the decoding site.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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