Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Virginia Murillo-Garzón; Irantzu Gorroño-Etxebarria; Malin Åkerfelt; Mikael Christer Puustinen; Lea Sistonen; Matthias Nees; James Carton; Jonathan Waxman; Robert M. Kypta

doi:10.1038/s41467-018-04042-w

Nature Communications (May 2018)

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Virginia Murillo-Garzón,
Irantzu Gorroño-Etxebarria,
Malin Åkerfelt,
Mikael Christer Puustinen,
Lea Sistonen,
Matthias Nees,
James Carton,
Jonathan Waxman,
Robert M. Kypta

Affiliations

Virginia Murillo-Garzón: Center for Cooperative Research in Biosciences, CIC bioGUNE
Irantzu Gorroño-Etxebarria: Center for Cooperative Research in Biosciences, CIC bioGUNE
Malin Åkerfelt: Institute of Biomedicine, University of Turku
Mikael Christer Puustinen: Faculty of Science and Engineering, Åbo Akademi University
Lea Sistonen: Faculty of Science and Engineering, Åbo Akademi University
Matthias Nees: Institute of Biomedicine, University of Turku
James Carton: Institute of Biomedicine, University of Turku
Jonathan Waxman: Department of Surgery and Cancer, Imperial College London
Robert M. Kypta: Center for Cooperative Research in Biosciences, CIC bioGUNE

DOI: https://doi.org/10.1038/s41467-018-04042-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Wnt11 has been shown to play a role in invasion and metastasis of prostate cancer. Here the authors show that in prostate cancer cells Wnt11 signals through the Fzd8 receptor and report an interaction between Fzd8 and TGF-β receptors regulating the transcription of a subset of TGF-beta genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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