Biochemical and echocardiographic markers for the early detection of cardiotoxicity under monoclonal antibodies therapy

Abstract

The progress made over the past years in the field of cancer therapy has led to a significant decrease in cancer mortality, but these therapies have many adverse effects, cardiovascular effects being among the most frequent ones. For increasing lifelong expectancy of surviving cancer patients, cardiac monitoring represents an important task. Current studies and practice recommend echocardiography using strain analysis for monitoring the cardio toxic effects of cancer therapy. The potential of combining imaging techniques with biomarkers for the early detection and diagnosis seems a promising path for future research.

Keywords

• cardiotoxicity
• troponins
• natriuretic peptides
• galectins
• global longitudinal strain