Nature Communications (Jul 2019)
Paternal-age-related de novo mutations and risk for five disorders
- Jacob L. Taylor,
- Jean-Christophe P. G. Debost,
- Sarah U. Morton,
- Emilie M. Wigdor,
- Henrike O. Heyne,
- Dennis Lal,
- Daniel P. Howrigan,
- Alex Bloemendal,
- Janne T. Larsen,
- Jack A. Kosmicki,
- Daniel J. Weiner,
- Jason Homsy,
- Jonathan G. Seidman,
- Christine E. Seidman,
- Esben Agerbo,
- John J. McGrath,
- Preben Bo Mortensen,
- Liselotte Petersen,
- Mark J. Daly,
- Elise B. Robinson
Affiliations
- Jacob L. Taylor
- Department of Psychiatry, Brigham and Woman’s Hospital
- Jean-Christophe P. G. Debost
- National Centre for Register-based Research, Department of Economics and Business, Aarhus University
- Sarah U. Morton
- Division of Newborn Medicine, Boston Children’s Hospital and Harvard Medical School
- Emilie M. Wigdor
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Henrike O. Heyne
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Dennis Lal
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Daniel P. Howrigan
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Alex Bloemendal
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Janne T. Larsen
- National Centre for Register-based Research, Department of Economics and Business, Aarhus University
- Jack A. Kosmicki
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Daniel J. Weiner
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Jason Homsy
- Department of Genetics, Harvard Medical School
- Jonathan G. Seidman
- Department of Genetics, Harvard Medical School
- Christine E. Seidman
- Department of Genetics, Harvard Medical School
- Esben Agerbo
- National Centre for Register-based Research, Department of Economics and Business, Aarhus University
- John J. McGrath
- National Centre for Register-based Research, Department of Economics and Business, Aarhus University
- Preben Bo Mortensen
- National Centre for Register-based Research, Department of Economics and Business, Aarhus University
- Liselotte Petersen
- National Centre for Register-based Research, Department of Economics and Business, Aarhus University
- Mark J. Daly
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- Elise B. Robinson
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- DOI
- https://doi.org/10.1038/s41467-019-11039-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
Advanced paternal age associates with increased risk for psychiatric and developmental disorders in offspring. Here, Taylor et al. utilize parent-child trio exome sequencing data sets to estimate the contribution of paternal age-related de novo mutations to multiple disorders, including heart disease and schizophrenia.
