Auditory steady-state response to chirp-modulated tones: A pilot study in patients with disorders of consciousness

Abstract

Objective: Due to the problems with behavioral diagnosis of patients with prolonged DOC (disorders of consciousness), complementary approaches based on objective measurement of neural function are necessary. In this pilot study, we assessed the sensitivity of auditory chirp-evoked responses to the state of patients with severe brain injury as measured with CRS-R (Coma Recovery Scale - Revised). Methods: A convenience sample of fifteen DOC patients was included in the study. Auditory stimuli, chirp-modulated at 1–120 Hz were used to evoke auditory steady-state response (ASSR). Phase-locking index (PLI) estimates within low gamma and high gamma windows were evaluated. Results: The PLI estimates within a narrow low gamma 38–42 Hz window positively correlated with the CRS-R total score and with the scores of the Auditory and Visual Function subscales. In the same low gamma window, significant difference in the PLIs was found between minimally conscious (MCS) and vegetative state (VS) patients. We did not observe any between-group differences nor any significant correlations with CRS-R scores in the high gamma window (80–110 Hz). Conclusions: Our results support the notion that the activity around 40 Hz may serve as a possible marker of the integrity of thalamocortical networks in prolonged DOC patients. Significance: Auditory steady-state responses at gamma-band frequencies highlight the role of upper parts of auditory system in evaluation of the level of consciousness in DOC patients.

Keywords

• Auditory steady-state response
• Chirp-modulated tones
• Disorders of consciousness
• Crs-r score
• Auditory system
• Electroencephalography