Srpski Arhiv za Celokupno Lekarstvo (Jan 2017)

Association of alpha-1 antitrypsin level and lung function in patients with chronic obstructive pulmonary disease

  • Serapinas Danielius,
  • Nutautiene Ruta,
  • Pukinskaite Ruta,
  • Bartkeviciene Daiva,
  • Barkauskiene Diana,
  • Sakalauskas Raimundas

DOI
https://doi.org/10.2298/SARH160809148S
Journal volume & issue
Vol. 145, no. 11-12
pp. 580 – 583

Abstract

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Introduction/Objective. Alpha-1 antitrypsin deficiency is a well established inherited risk factor for chronic obstructive pulmonary disease (COPD); however, alpha-1 antitrypsin level may result in different lung function reduction. The aim of our study was to evaluate possible associations of alpha-1 antitrypsin level and lung function in COPD patients with different alpha-1 antitrypsin phenotypes. Methods. Serum alpha-1 antitrypsin concentration from patients (n = 1,167) with COPD, defined according to the GOLD criteria, were analyzed by nephelometry, and alpha-1 antitrypsin phenotype was determined by means of isoelectric-focusing. Results. In COPD patients without alpha-1 antitrypsin deficiency (MM), a significant negative association of lung function (FEV1) with serum alpha-1 antitrypsin (r = -0.511; p < 0.05) and C-reactive protein (CRP) concentrations (r = -0.583; p < 0.05) was detected; moreover, the level of alpha-1 antitrypsin positively correlated with CRP concentration (r = 0.667; p < 0.05). Conclusions. In patients without alpha-1 antitrypsin deficiency, detected negative association of alpha-1 antitrypsin level with FEV1 and positive association with the CRP level defined the importance of alpha-1 antitrypsin for lung function in COPD patients.

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