Brain Stimulation (Sep 2020)

Non-invasive vagal nerve stimulation decreases brain activity during trauma scripts

  • Matthew T. Wittbrodt,
  • Nil Z. Gurel,
  • Jonathon A. Nye,
  • Stacy Ladd,
  • Md Mobashir H. Shandhi,
  • Minxuan Huang,
  • Amit J. Shah,
  • Bradley D. Pearce,
  • Zuhayr S. Alam,
  • Mark H. Rapaport,
  • Nancy Murrah,
  • Yi-An Ko,
  • Ammer A. Haffer,
  • Lucy H. Shallenberger,
  • Viola Vaccarino,
  • Omer T. Inan,
  • J. Douglas Bremner

Journal volume & issue
Vol. 13, no. 5
pp. 1333 – 1348

Abstract

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Background: Traumatic stress can have lasting effects on neurobiology and result in psychiatric conditions such as posttraumatic stress disorder (PTSD). We hypothesize that non-invasive cervical vagal nerve stimulation (nVNS) may alleviate trauma symptoms by reducing stress sympathetic reactivity. This study examined how nVNS alters neural responses to personalized traumatic scripts. Methods: Nineteen participants who had experienced trauma but did not have the diagnosis of PTSD completed this double-blind sham-controlled study. In three sequential time blocks, personalized traumatic scripts were presented to participants immediately followed by either sham stimulation (n = 8; 0–14 V, 0.2 Hz, pulse width = 5s) or active nVNS (n = 11; 0–30 V, 25 Hz, pulse width = 40 ms). Brain activity during traumatic scripts was assessed using High Resolution Positron Emission Tomography (HR-PET) with radiolabeled water to measure brain blood flow. Results: Traumatic scripts resulted in significant activations within the bilateral medial and orbital prefrontal cortex, premotor cortex, anterior cingulate, thalamus, insula, hippocampus, right amygdala, and right putamen. Greater activation was observed during sham stimulation compared to nVNS within the bilateral prefrontal and orbitofrontal cortex, premotor cortex, temporal lobe, parahippocampal gyrus, insula, and left anterior cingulate. During the first exposure to the trauma scripts, greater activations were found in the motor cortices and ventral visual stream whereas prefrontal cortex and anterior cingulate activations were more predominant with later script presentations for those subjects receiving sham stimulation. Conclusion: nVNS decreases neural reactivity to an emotional stressor in limbic and other brain areas involved in stress, with changes over repeated exposures suggesting a shift from scene appraisal to cognitively processing the emotional event.

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