Th2 and eosinophil responses suppress inflammatory arthritis

Zhu Chen; Darja Andreev; Katharina Oeser; Branislav Krljanac; Axel Hueber; Arnd Kleyer; David Voehringer; Georg Schett; Aline Bozec

doi:10.1038/ncomms11596

Nature Communications (Jun 2016)

Th2 and eosinophil responses suppress inflammatory arthritis

Zhu Chen,
Darja Andreev,
Katharina Oeser,
Branislav Krljanac,
Axel Hueber,
Arnd Kleyer,
David Voehringer,
Georg Schett,
Aline Bozec

Affiliations

Zhu Chen: Department of Internal Medicine 3, University Hospital Erlangen and Friedrich Alexander University of Erlangen-Nuremberg
Darja Andreev: Department of Internal Medicine 3, University Hospital Erlangen and Friedrich Alexander University of Erlangen-Nuremberg
Katharina Oeser: Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU)
Branislav Krljanac: Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU)
Axel Hueber: Department of Internal Medicine 3, University Hospital Erlangen and Friedrich Alexander University of Erlangen-Nuremberg
Arnd Kleyer: Department of Internal Medicine 3, University Hospital Erlangen and Friedrich Alexander University of Erlangen-Nuremberg
David Voehringer: Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU)
Georg Schett: Department of Internal Medicine 3, University Hospital Erlangen and Friedrich Alexander University of Erlangen-Nuremberg
Aline Bozec: Department of Internal Medicine 3, University Hospital Erlangen and Friedrich Alexander University of Erlangen-Nuremberg

DOI: https://doi.org/10.1038/ncomms11596
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Type 2 immune responses are viewed as opposites of Type 1 and 17 responses. Here the authors show that activation of Type 2 immunity by helminth infection counteracts the development of inflammatory arthritis, a type 17-mediated pathology, via IL-4/IL-13- STAT6 signalling and eosinophil activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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