PLoS Genetics (Jan 2012)

Genome-wide association and functional follow-up reveals new loci for kidney function.

  • Cristian Pattaro,
  • Anna Köttgen,
  • Alexander Teumer,
  • Maija Garnaas,
  • Carsten A Böger,
  • Christian Fuchsberger,
  • Matthias Olden,
  • Ming-Huei Chen,
  • Adrienne Tin,
  • Daniel Taliun,
  • Man Li,
  • Xiaoyi Gao,
  • Mathias Gorski,
  • Qiong Yang,
  • Claudia Hundertmark,
  • Meredith C Foster,
  • Conall M O'Seaghdha,
  • Nicole Glazer,
  • Aaron Isaacs,
  • Ching-Ti Liu,
  • Albert V Smith,
  • Jeffrey R O'Connell,
  • Maksim Struchalin,
  • Toshiko Tanaka,
  • Guo Li,
  • Andrew D Johnson,
  • Hinco J Gierman,
  • Mary Feitosa,
  • Shih-Jen Hwang,
  • Elizabeth J Atkinson,
  • Kurt Lohman,
  • Marilyn C Cornelis,
  • Åsa Johansson,
  • Anke Tönjes,
  • Abbas Dehghan,
  • Vincent Chouraki,
  • Elizabeth G Holliday,
  • Rossella Sorice,
  • Zoltan Kutalik,
  • Terho Lehtimäki,
  • Tõnu Esko,
  • Harshal Deshmukh,
  • Sheila Ulivi,
  • Audrey Y Chu,
  • Federico Murgia,
  • Stella Trompet,
  • Medea Imboden,
  • Barbara Kollerits,
  • Giorgio Pistis,
  • CARDIoGRAM Consortium,
  • ICBP Consortium,
  • CARe Consortium,
  • Wellcome Trust Case Control Consortium 2 (WTCCC2),
  • Tamara B Harris,
  • Lenore J Launer,
  • Thor Aspelund,
  • Gudny Eiriksdottir,
  • Braxton D Mitchell,
  • Eric Boerwinkle,
  • Helena Schmidt,
  • Margherita Cavalieri,
  • Madhumathi Rao,
  • Frank B Hu,
  • Ayse Demirkan,
  • Ben A Oostra,
  • Mariza de Andrade,
  • Stephen T Turner,
  • Jingzhong Ding,
  • Jeanette S Andrews,
  • Barry I Freedman,
  • Wolfgang Koenig,
  • Thomas Illig,
  • Angela Döring,
  • H-Erich Wichmann,
  • Ivana Kolcic,
  • Tatijana Zemunik,
  • Mladen Boban,
  • Cosetta Minelli,
  • Heather E Wheeler,
  • Wilmar Igl,
  • Ghazal Zaboli,
  • Sarah H Wild,
  • Alan F Wright,
  • Harry Campbell,
  • David Ellinghaus,
  • Ute Nöthlings,
  • Gunnar Jacobs,
  • Reiner Biffar,
  • Karlhans Endlich,
  • Florian Ernst,
  • Georg Homuth,
  • Heyo K Kroemer,
  • Matthias Nauck,
  • Sylvia Stracke,
  • Uwe Völker,
  • Henry Völzke,
  • Peter Kovacs,
  • Michael Stumvoll,
  • Reedik Mägi,
  • Albert Hofman,
  • Andre G Uitterlinden,
  • Fernando Rivadeneira,
  • Yurii S Aulchenko,
  • Ozren Polasek,
  • Nick Hastie,
  • Veronique Vitart,
  • Catherine Helmer,
  • Jie Jin Wang,
  • Daniela Ruggiero,
  • Sven Bergmann,
  • Mika Kähönen,
  • Jorma Viikari,
  • Tiit Nikopensius,
  • Michael Province,
  • Shamika Ketkar,
  • Helen Colhoun,
  • Alex Doney,
  • Antonietta Robino,
  • Franco Giulianini,
  • Bernhard K Krämer,
  • Laura Portas,
  • Ian Ford,
  • Brendan M Buckley,
  • Martin Adam,
  • Gian-Andri Thun,
  • Bernhard Paulweber,
  • Margot Haun,
  • Cinzia Sala,
  • Marie Metzger,
  • Paul Mitchell,
  • Marina Ciullo,
  • Stuart K Kim,
  • Peter Vollenweider,
  • Olli Raitakari,
  • Andres Metspalu,
  • Colin Palmer,
  • Paolo Gasparini,
  • Mario Pirastu,
  • J Wouter Jukema,
  • Nicole M Probst-Hensch,
  • Florian Kronenberg,
  • Daniela Toniolo,
  • Vilmundur Gudnason,
  • Alan R Shuldiner,
  • Josef Coresh,
  • Reinhold Schmidt,
  • Luigi Ferrucci,
  • David S Siscovick,
  • Cornelia M van Duijn,
  • Ingrid Borecki,
  • Sharon L R Kardia,
  • Yongmei Liu,
  • Gary C Curhan,
  • Igor Rudan,
  • Ulf Gyllensten,
  • James F Wilson,
  • Andre Franke,
  • Peter P Pramstaller,
  • Rainer Rettig,
  • Inga Prokopenko,
  • Jacqueline C M Witteman,
  • Caroline Hayward,
  • Paul Ridker,
  • Afshin Parsa,
  • Murielle Bochud,
  • Iris M Heid,
  • Wolfram Goessling,
  • Daniel I Chasman,
  • W H Linda Kao,
  • Caroline S Fox

DOI
https://doi.org/10.1371/journal.pgen.1002584
Journal volume & issue
Vol. 8, no. 3
p. e1002584

Abstract

Read online

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.