Nature Communications (Apr 2020)
A salvage pathway maintains highly functional respiratory complex I
- Karolina Szczepanowska,
- Katharina Senft,
- Juliana Heidler,
- Marija Herholz,
- Alexandra Kukat,
- Michaela Nicole Höhne,
- Eduard Hofsetz,
- Christina Becker,
- Sophie Kaspar,
- Heiko Giese,
- Klaus Zwicker,
- Sergio Guerrero-Castillo,
- Linda Baumann,
- Johanna Kauppila,
- Anastasia Rumyantseva,
- Stefan Müller,
- Christian K. Frese,
- Ulrich Brandt,
- Jan Riemer,
- Ilka Wittig,
- Aleksandra Trifunovic
Affiliations
- Karolina Szczepanowska
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Katharina Senft
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Juliana Heidler
- Functional Proteomics, ZBC, Faculty of Medicine, Goethe University
- Marija Herholz
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Alexandra Kukat
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Michaela Nicole Höhne
- Department of Chemistry, Institute of Biochemistry, University of Cologne
- Eduard Hofsetz
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Christina Becker
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Sophie Kaspar
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Heiko Giese
- Molecular Bioinformatics, Goethe-Universität Frankfurt am Main
- Klaus Zwicker
- Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt
- Sergio Guerrero-Castillo
- Nijmegen Centre for Mitochondrial Disorders, Radboud University Medical Center
- Linda Baumann
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Johanna Kauppila
- Department of Mitochondrial Biology, Max Planck Institute for Biology of Aging
- Anastasia Rumyantseva
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Stefan Müller
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Christian K. Frese
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Ulrich Brandt
- Nijmegen Centre for Mitochondrial Disorders, Radboud University Medical Center
- Jan Riemer
- Department of Chemistry, Institute of Biochemistry, University of Cologne
- Ilka Wittig
- Functional Proteomics, ZBC, Faculty of Medicine, Goethe University
- Aleksandra Trifunovic
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- DOI
- https://doi.org/10.1038/s41467-020-15467-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Maintenance and quality control of the mitochondrial respiratory chain complexes responsible for bulk energy production are unclear. Here, the authors show that the mitochondrial protease ClpXP is required for the rapid turnover of the core N-module of respiratory complex I, which happens independently of other modules in the complex.
