ROS‐scavenging and antimicrobial polysaccharide hydrogel for methicillin‐resistant staphylococcus aureus‐infected diabetic wound healing

Abstract

Abstract Bacterial infection can cause delay in wound healing, and reactive oxygen species (ROS) was accumulated in wounds, which threaten patients’ lives. Therefore, it needs to develop a multifunctional hydrogel for infected wound healing. Here, a multifunctional QAS‐CS@GA‐GM hydrogel with antibacterial and antioxidant property, established by the self‐adaptive covalent bond, is prepared aiming to eradicate bacteria and eliminate ROS. It is observed that QAS‐CS@GA‐GM hydrogel displays remarkable ability of clearing ROS and killing bacteria in vitro. With its antibacterial and antioxidant activity, QAS‐CS@GA‐GM hydrogel significantly accelerates the MRSA‐infected wound closure and reduces inflammatory, when QAS‐CS@GA‐GM hydrogel was applied to wound sites. Collectively, the research suggests that a self‐adaptive QAS‐CS@GA‐GM hydrogel is a promising wound dressing as antibacterial and ROS‐scavenging dressing for bacterial‐infected wound.

Keywords

• antibacterial hydrogel
• dynamic covalent bond
• MRSA infection
• ROS
• wound healing