INFLUENCE OF FINGOLIMOD ON NON-RESPIRATORY FUNCTIONS OF LUNGS IN ANTIPHOSPHOLIPID SYNDROME

Abstract

Objective – the role of immunosuppressive mechanisms in the correction of respiratory system dysfunctions associated with autoimmune pathology (antiphospholipid syndrome). The aim of the study was to study the effect of the immunosuppressive drug fingolimod on non-respiratory functions of the lungs in antiphospholipid syndrome. Methods. The experiments were carried out on 70 white outbred male rats. The rats of the 1st group were administered with cardiolipin antigen (0.2-0.4 mg per animal every other day for 3 weeks) to simulate antiphospholipid syndrome. Antiphospholipid syndrom in animals of the 2nd group was combined with the administration of fingolimod (1 mg / kg). The 3nd (control) group consisted of rats, which were injected with vehicle (0.9% NaCl) according to the same scheme. The complex of explored biophysical and biochemical parameters included surfactant composition and activity, pulmonary water balance and blood supply, and nitroxydergic activity of the lung. Statistical analysis of the obtained results was carried out using the SPSS 22 program. Results. We have found that, in experimental antiphospholipid syndrome, the biophysical properties of surfactant decreased simultaneously with lung hyperhydration and impaired nitroxydergic activity. Fingolimod restored the parameters of surfactant, water balance and nitroxydergic activity of the lung, altered in antiphospholipid syndrome. Conclusion. The results of the study indicate the effectiveness of immunosuppression in restoration of non-respiratory functions of the lung revealed in simulated systemic autoimmune pathology, antiphospholipid syndrome.

Keywords

• антифосфолипидный синдром
• нереспираторные функции лёгких
• финголимод