Evaluation of Genotoxic effects of a Hydro-alcoholic extract of flowers of Nargis (Narcissus Tazetta L.)

Abstract

The goal of this study was to determine the genotoxic potential of a hydroalcoholic extract of Nargis flowers (Narcissus Tazetta L.). The genotoxicity potential of standardized hydroalcoholic extract of Narcissus Tazetta L at different concentrations was assessed using human breast cancer cells applying the MTT test for cell cytotoxicity. In control cells, Nargis flowers extract did not totally break DNA, however, flowers-treated cells showed high amounts of damage in a dose-dependent way. According to the findings, the crude hydroalcoholic extract of Narcissus Tazetta (Nargis flowers) had a potent inhibitory effect on human breast carcinoma cancer cell proliferation, which was mediated by its pro-apoptotic antiproliferative activity.

Keywords

• hydroalcoholic extract
• narcissus tazetta l.
• breast carcinoma
• apoptotic