8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage

Chi-I Chang; Wan-Chiao Hu; Che-Piao Shen; Ban-Dar Hsu; Wei-Yong Lin; Ping-Jyun Sung; Wei-Hsien Wang; Jin-Bin Wu; Yueh-Hsiung Kuo

doi:10.3390/ijms15034608

International Journal of Molecular Sciences (Mar 2014)

8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage

Chi-I Chang,
Wan-Chiao Hu,
Che-Piao Shen,
Ban-Dar Hsu,
Wei-Yong Lin,
Ping-Jyun Sung,
Wei-Hsien Wang,
Jin-Bin Wu,
Yueh-Hsiung Kuo

Affiliations

Chi-I Chang: Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
Wan-Chiao Hu: Department of Chemistry, National Taiwan University, Taipei 106, Taiwan
Che-Piao Shen: Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan
Ban-Dar Hsu: Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan
Wei-Yong Lin: Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan
Ping-Jyun Sung: Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Wei-Hsien Wang: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Jin-Bin Wu: Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan
Yueh-Hsiung Kuo: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan

DOI: https://doi.org/10.3390/ijms15034608
Journal volume & issue: Vol. 15, no. 3
pp. 4608 – 4618

Abstract

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Three new 8-alkylcoumarins, 7-O-methylphellodenol-B (1), 7-methoxy-8-(3-methyl- 2,3-epoxy-1-oxobutyl)chromen-2-one (2), and 3'-O-methylvaginol (3), together with seven known compounds (4–10) were isolated from the fruits of Cnidium monnieri. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. All the isolates were evaluated the cytoprotective activity by MTS cell proliferation assay and the results showed that all the three new 8-alkylcoumarins exhibited cytoprotective effect on Neuro-2a neuroblastoma cells injured by hydrogen peroxide.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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