Case Reports in Medicine (Jan 2013)

A Case of the Large Cell Neuroendocrine Carcinoma of the Urinary Bladder

  • Shinro Hata,
  • Yoshihisa Tasaki

DOI
https://doi.org/10.1155/2013/804136
Journal volume & issue
Vol. 2013

Abstract

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Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. Definite treatment strategy has not been established and prognosis of the disease is not clear yet. We report a case of primary LCNEC of the urinary bladder here with some review of the literature. The patient was a 84-year-old man. He underwent transurethral resection of bladder tumor (TURBT). Histological examination revealed a rosette arrangement of the tumor cells by HE staining and immunohistochemical study revealed positive CD 56, synaptophysin, and chromogranin A (LCNEC). After TURBT, he has no sign of recurrence for 8 months. We have to strictly observe the progress because LCNEC is very aggressive.