TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth

Maria-Vittoria Sepporta; Viviane Praz; Katia Balmas Bourloud; Jean-Marc Joseph; Nicolas Jauquier; Nicolò Riggi; Katya Nardou-Auderset; Audrey Petit; Jean-Yves Scoazec; Hervé Sartelet; Raffaele Renella; Annick Mühlethaler-Mottet

doi:10.1038/s42003-021-02958-6

Communications Biology (Jan 2022)

TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth

Maria-Vittoria Sepporta,
Viviane Praz,
Katia Balmas Bourloud,
Jean-Marc Joseph,
Nicolas Jauquier,
Nicolò Riggi,
Katya Nardou-Auderset,
Audrey Petit,
Jean-Yves Scoazec,
Hervé Sartelet,
Raffaele Renella,
Annick Mühlethaler-Mottet

Affiliations

Maria-Vittoria Sepporta: Pediatric Hematology-Oncology Research Laboratory, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne
Viviane Praz: Pediatric Hematology-Oncology Research Laboratory, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne
Katia Balmas Bourloud: Pediatric Hematology-Oncology Research Laboratory, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne
Jean-Marc Joseph: Pediatric Surgery, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne
Nicolas Jauquier: Pediatric Surgery, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne
Nicolò Riggi: Experimental Pathology, Lausanne University Hospital and University of Lausanne
Katya Nardou-Auderset: Pediatric Hematology-Oncology Research Laboratory, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne
Audrey Petit: Department of Pathology, Medical University of Grenoble
Jean-Yves Scoazec: Department of Biology and Medical Pathology, Gustave Roussy Cancer Campus
Hervé Sartelet: Department of Pathology, Medical University of Grenoble
Raffaele Renella: Pediatric Hematology-Oncology Research Laboratory, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne
Annick Mühlethaler-Mottet: Pediatric Hematology-Oncology Research Laboratory, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne

DOI: https://doi.org/10.1038/s42003-021-02958-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

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TWIST1 and TWIST2 were found to display an opposed expression pattern, with TWIST1 associated with poor survival and TWIST2 with good prognosis. Functional studies revealed that TWIST1 promotes both primary and metastatic neuroblastoma (NB) tumor growth. Further, a transcriptional signature of NB tumors with high levels of TWIST1 and associated with dismal outcome is provided, confirming TWIST1 as a promising therapeutic target in NB.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal