Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytes

Abstract

Lynette Naler and Yuan-Pang Hsieh et al. evaluate epigenomic and transcriptomic differences in mouse bone marrow-derived macrophages following exposure to high or low doses of LPS. Their results suggest that both low- and high-grade inflammation involve TRAM-dependent pathways.