Crystal structure of ethyl 2-(2,4,5-trimethoxyphenyl)quinoline-4-carboxylate

Abstract

In the title compound, C21H21NO5, the dihedral angle between the quinoline ring system (r.m.s. deviation = 0.028 Å) and the trimethoxybenzene ring is 43.38 (5)°. The C atoms of the methoxy groups deviate from their attached benzene ring by −0.396 (2), −0.049 (2) and 0.192 (2) Å for the ortho-, meta- and para-substituents, respectively. The pendant ethyl chain is disordered over two orientations in a 0.527 (5):0.473 (5) ratio. A short intramolecular C—H...O contact closes an S(6) ring. In the crystal, inversion dimers linked by pairs of weak C—H...O interactions generate R22(6) loops. The dimers are linked by further C—H...O interactions to generate [1-10] chains.

Keywords

• crystal structure
• quinoline
• quinolone-4-ethyl carboxylate
• hydrogen bonding
• C—H...O interactions